Endocrine Abstracts

Tpit is a pituitary-specific transcription factor that is important for corticotroph terminal differentiation. In TPit null mice corticotroph cells do not differentiate and cells immunopositive for SF1, LH and FSH are observed in the intermediate lobe (Pulichino et al. 2003 Genes Dev). As the anterior lobe in TPit null mice showed a 50% decrease in cell number compared to wild-type (WT), and corticotrophs comprise only 5–7% of anterior lobe cells, we investigated c...